PREVALENCE OF BRCA HOMOPOLYMERIC INDELS IN AN ION TORRENT-BASED TUMOUR-TO-GERMLINE TESTING WORKFLOW IN HIGH-GRADE OVARIAN CARCINOMA

Prevalence of BRCA homopolymeric indels in an ION Torrent-based tumour-to-germline testing workflow in high-grade ovarian carcinoma

Abstract Tumour DNA sequencing is essential for precision medicine since it guides therapeutic decisions but also fosters the identification of patients who may benefit from germline testing.Notwithstanding, the tumour-to-germline testing workflow presents a few caveats.The low sensitivity for indels at loci with sequences of identical bases (homop

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Recombinant ferritin-based nanoparticles as neoantigen carriers significantly inhibit tumor growth and metastasis

Abstract Background Tumor neoantigen peptide-based vaccines, systemic immunotherapies that enhance antitumor immunity by activating and expanding antigen-specific T cells, have achieved remarkable results in the treatment of a procharger ram 1500 5.7 variety of solid tumors.However, how to effectively deliver neoantigens to induce robust antitumor

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WORKPLANS: Workshop on Planetary Nebula Observations

This workshop is the second of the WORKPLANS series, which we started in 2016.The main goal of WORKPLANS is to build up a network of planetary nebulae (PNe) experts to address the main open questions in the field of PNe research.The specific aims of the WORKPLANS workshop series are (i) to discuss and prioritize the most important topics to be inve

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